Clomiphene citrate, Clomid for ovulation induction
Clomid is the most common oral fertility medication used for ovulation induction. Clomiphene Citrate was approved by the FDA in the U.S. in 1967 to induce ovulation. It is sold under the brand names Clomid or Serophene. It induces ovulation in over 50% of women who take it by making your body believe it has less estrogen than it actually does.
Clomiphene Citrate is the most commonly prescribed medicine to induce ovulation.
Ovulation, which is essential for your regular menstrual cycle and for pregnancy, is preceded by a chain of events involving several hormones that begins prior to your menstrual cycle. Clomiphene Citrate works by influencing the interaction of the following hormones: GnRH (gonadotropin-releasing hormone), FSH (follicle stimulating hormone), LH (luteinizing hormone), and estradiol. Clomid blocks estrogen receptors, which results in increased FSH production and enhanced follicle stimulation and ovulation.
Possible side effects of Clomid
- hot flashes
- breast tenderness
- mood swings
Once the medication is stopped, the side effects will subside
Risk for Multiples with Clomid
When taking Clomiphene, there is a 10% chance of having twins, but triplets or higher order multiples are rare, happening less than 1% of the time.
How is Clomid Dosed?
Clomiphene Citrate is taken in pill form once a day for five days, usually beginning on day 3 of your cycle. Ovulation normally occurs five to nine days after the last dose of Clomiphene Citrate. If you don’t menstruate and pregnancy is excluded, bleeding can be started with medications such as progesterone.
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