Preimplantation genetic screening can help you make informed decisions about fertility
Preimplantation genetic screening, or PGS, at our Nashville fertility clinic is recommended for patients who are concerned about chromosomal abnormalities, are older than 35, have experienced recurrent miscarriages or repeated IVF failure or have unexplained infertility. PGS provides valuable information that can help men and women have healthy families.
What is preimplantation genetic screening?
Preimplantation genetic screening involves multiple steps at our Nashville fertility clinic.
- Our embryologists biopsy an embryo by removing a sample of multiple cells from the outer layer on Day 5 or Day 6 of development in the lab. It’s common for a sample of the cells that will become the placenta to be removed, while the inner cell mass, which will become the fetus, are left undisturbed. The risk to the embryo during the biopsy is very low.
- After our embryologists remove a sample of cells, the embryos are frozen using a process called vitrification. The embryos stay frozen in the IVF laboratory and the biopsied cells are sent to a reference genetics lab for testing. The reference lab for our Nashville fertility clinic is Ovation Fertility™, a leader in preimplantation genetic testing.
- At the reference lab, embryologists count the number of chromosomes in each sample. Most humans have a total of 23 pairs of chromosomes. If an embryo has too many or too few chromosomes, it may have chromosomal problems.
- It generally takes seven to 10 days before the results are ready to be sent from the lab to the fertility clinic. After the fertility clinic receives the report, they will discuss the results with the patient.
How screening is used
PGS is used to screen embryos to ensure each one contains the correct number of chromosomes, but it cannot detect specific genetic disorders.
By utilizing preimplantation genetic screening, our Nashville fertility clinic is better equipped to determine which embryos are genetically normal, helping to prevent the transfer of embryos that have a higher likelihood of resulting in a variety of problems.
- Implantation failure
- Chromosomal disorders like Down syndrome or Turner syndrome
- Other issues that may cause a fertility treatment to fail
In addition, PGS at our Nashville fertility clinic helps to prevent pregnancies with multiples because physicians are able to transfer one embryo at a time, and the embryo that is transferred will have a higher chance of resulting in a viable pregnancy.
At our Nashville fertility clinic we believe preimplantation genetic screening is a helpful tool in identifying embryos that are good candidates for transfer, and will continue our research as the field of PGS evolves. Contact us for more information.