Nashville Fertility

PGS Versus PGD

The difference between PGS versus PGD

The difference between PGS versus PGDOur Nashville fertility specialists know that it can be tricky to figure out the difference between PGS versus PGD. First, let’s demystify the acronyms. PGS stands for preimplantation genetic screening, and PGD stands for preimplantation genetic diagnosis. While the terms screening and diagnosis seem similar they have different meanings in the world of fertility.

What is PGS versus PGD?

PGS and PGD both fall under the umbrella of preimplantation genetic testing, or PGT. Our Nashville fertility specialists have found that both types of testing can help you have a healthy baby.

PGS is a form of testing that screens cells in embryos for abnormalities in the number of chromosomes, or evaluates whether part of a chromosome has broken off and reattached on another chromosome, which is known as a translocation.

  • PGS does not test for a specific genetic disease or disorder.
  • PGS is used to detect aneuploidy, having too few or too many chromosomes. Aneuploidy could cause miscarriage, implantation failure or chromosomal disorders like Turner syndrome or Down syndrome.
  • PGD is able to distinguish between normal embryos and those with specific inheritable genetic diseases or disorders.
  • PGD can also be used to determine the sex of the embryo, helping to prevent the transfer of an embryo that could develop a sex-linked disorder.

A patient’s medical history is an important factor when deciding between PGS versus PGD.

Who can benefit from PGS and PGD?

While PGS and PGD both help to ensure that your fertility specialist only transfers genetically normal embryos, some patients are better candidates for PGS versus PGD.

  • Couples who have no known inheritable genetic disorders, but who are of advanced maternal age, have experienced recurrent miscarriages or failed IVF cycles, could benefit from PGS.
  • Couples who carry an inheritable genetic disorder, like cystic fibrosis or spinal muscular atrophy, could be candidates for PGD, which would screen for the specific disorder.

Our Nashville fertility specialists know how challenging it can be to decide if PGS versus PGD is right for you, and are here to offer guidance. Contact us for more information.


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